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Seizure prophylaxis following traumatic brain injury

…Trauma Foundation. J Neurotrauma 2007;24(suppl 1); free full supplement at www.braintrauma.org/pdf/protected/Guidelines_Management_2007w_bookmarks.pdf). A review of antiepileptics for TBI recommends phenytoin since it has been most extensively studied (Torbic et al. Am J Health Syst Pharm 2013;70:759-766). Other agents (e.g. phenobarbital, valproate, carbamazepine) have not been researched to the same degree and are not generally preferred over ph…

Inappropriate prescribing common in AD patients

…nappropriate medications (Holt et al. Dtsch Arztebl Int 2010;107: 543-551; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC2933536/pdf/Dtsch_Arztebl_Int-107-0543.pdf). A study at the University of Cologne has used PRISCUS to examine the PIM prevalence in community-living elderly based on health claims data (Schubert et al. Pharmacoepidemiol Drug Saf 2013; epublished April 12, 2013). An estimated 22% of the elderly population received at lea…

MS therapies: analyses and re-analyses of phase III studies

…Q2W dosing had a more pronounced effect on MRI measures. Disease activity-free rates: The proportion of patients who were disease activity-free (no relapses, EDSS progression or new MRI lesions) was reported for three studies. In the ADVANCE study (above), DAF rates at 12 months were 34% with peg-IFN Q2W and 22% with Q4W. DAF rates for natalizumab were determined in a retrospective analysis of the AFFIRM trial (Havrdova et al. Lancet Neurol 2009;…

New review of PD pathophysiology

…events interact in PD that readers may find useful for teaching purposes. Free full text is available at: www.frontiersin.org/Neurodegeneration/10.3389/fneur.2013.00033/abstract. Comment Dr. Michel Panisset: Although the cause for Parkinson’s disease is still unknown, new data are helping to open up new avenues for investigations, e.g. gastrointestinal involvement, increased absorption and mesenteric plexus Lewy bodies, and the prion-like behavio…

Guidelines on managing bipolar disorder: CANMAT 2013 update

The Canadian Network for Mood and Anxiety Disorders (CANMAT) has produced an update of its guidelines for the management of patients with bipolar disorder (Yatham et al. Bipolar Disord 2013;15:1-44). The guidelines were produced in conjunction with the International Society for Bipolar Disorders. Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Cont…