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Heart disease associated with atrophy in MS

…; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC6026666/pdf/fneur-09-00487.pdf). Overall, 29.5% of MS patients were normotensive, 52.6% were prehypertensive (SBP 120-139/DBP 80-89) and 17.9% were hypertensive (SBP >140/DBP >90); according to 2017 guidelines, 29% were normotensive, 18% had elevated BP (SBP 120-129/DBP < 80) and 53% were hypertensive (SBP >130/DBP >80). Increasingly high systolic BP was associated with damage to posterior…

Predictors of switching therapies in MS – real-world results

…1) compared to an interferon. Switching due to intolerance/safety was more common in patients with comorbidities (HR 1.28) and those on natalizumab (HR 1.43). A separate study also reported that patients with higher socioeconomic status were more able to access second-line therapies (Calocer et al. PLoS One 2018;13:e0191646). While several groups have outlined clinical/radiological criteria for an inadequate treatment response, many patients are n…

Inhibiting CGRP in migraine prophylaxis

…days with photophobia and phonophobia during the 12-week study period. Long-term data were also reported. A one-year study enrolled subjects from two prior studies as well as 312 new subjects with chronic or episodic migraine (Goadsby et al. AHS 2018; abstract PS30). For the interim analysis, the mean change from baseline to month 6 in MMD was -27.9 days and -26.5 days with monthly and quarterly dosing for the chronic migraine cohort, and -24.9 an…

Emerging approach to improve functional recovery post-stroke

…d in the METASTROKE meta-analysis (Traylor et al. Lancet Neurol 2012;11:951-962). A population-based analysis found that one HDAC9 polymorphism (rs2107595) was associated with carotid intima-media thickness and with the presence of carotid plaques (Markus et al. Stroke 2013;44:1220-1225). A pilot study subsequently reported that this same polymorphism was associated with upregulation of pathways associated with IL-6 signalling, cholesterol efflux…

Exploring therapeutic inertia in multiple sclerosis

…5; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC5331032/pdf/fneur-08-00065.pdf). Participants also completed surveys about their aversion to ambiguity in financial and clinical areas and risk preferences in different domains. A total of 135 neurologists (mean age 39.5 years) in Spain participated; 96 completed the surveys. Two-thirds of respondents’ practices focused on MS care. Clinicians had worked a mean 14 years in practice, seeing a…