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Targeting glutamate: the end of the monoamine hypothesis?

December 5, 2012

A number of recent papers have focused attention on the remarkable responses seen with glutamatergic agents in major depressive disorder (MDD), raising questions about the monoamine hypothesis of psychiatric disorders that has dominated biological psychiatry for a half century (Schildkraut JJ. Am J Psychiatry 1965;122:509-522). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you reg…

Neuroprotection: This is your brain on tea

December 5, 2012

The latest claimant to the neuroprotection crown is green tea, which provides therapeutic levels of the antioxidant EGCG (epigallocatechin gallate). A number of animal studies have indicated that EGCG may be beneficial in a range of disorders, including arthritis, colitis, Sjogren’s syndrome, and type 1 diabetes (Kim et al. J Nutr 2008;138:2111-2116; Oz et al. J Nutr Biochem 2005;16:297-304; Hsu et al. Autoimmunity 2007;40:138-147; Fu et al. Br J…

The woes of neurology drug development: Eli Lilly

November 21, 2012

…The difficulties of developing new therapies for neurological disorders is well documented (see CNS drug development: a pipeline of problems, Neurosens, November 9, 2011). The most recent case in point: Eli Lilly, which has had a tough summer with two of its late-stage drugs. Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…

Testing the new NIA-AA criteria for MCI

November 21, 2012

…A European group has examined the risk of progression to Alzheimer’s disease for the four MCI subgroups outlined in the National Institute on Aging-Alzheimer’s Association (NIA-AA) recommendations (Guo et al. Eur Arch Psychiatry Clin Neurosci 2012; epublished August 30, 2012). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…

GDS recommended for depression screening in PD

November 21, 2012

The Methods of Optimal Depression Detection in Parkinson’s Disease (MOOD-PD) study has reviewed patient self-report scales, concluding that the 30-item Geriatric Depression Scale (GDS) is the most efficient tool to screen for clinical depression in PD patients (Williams et al. Neurology 2012;78:998-1006). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter…