…Includes an overview of SARS-CoV-2 pathogenesis; the neuroinvasive potential of coronaviruses; proposed mechanisms of CNS invasion with SARS-CoV-2 and possible neuropathological mechanisms; case reports of neurological complications; and recommendations from the European Academy of Neurology. Download the Neurological Complications of COVID-19 slide deck…
…e considered the pathological correlate of MS disease progression. The post-mortem study examined 21 SELs (mixed active/inactive and demyelinating lesions) from 13 patients with progressive MS aged 30-74 years. Additional tissue samples (chronic inactive lesions, normal-appearing white matter) were also examined. SELs were completely demyelinated and had a rim of macrophages/microglia at the lesion edge; this rim of macrophages/microglia was absen…
…Summary of epidemiology, testing and mortality rate; Canada and world statistics. Download COVID-19 slide deck…
…structural proteins (e.g. nucleocapsid protein, NP). Remarkably, a SARS-CoV-2-specific T cell response was also seen in 19 of 37 individuals who had never been exposed to CoV-2 or SARS. The memory T cell response differed depending on prior virus exposure: SARS and COVID-19 patients reacted primarily to NP peptides whereas unexposed individuals had a mixed response to structural (e.g. NP) and non-structural (e.g. NSP7/13) peptides. These findings…
…udinal study obtained serum NfL values in 814 CIS/RRMS patients over a four-year follow-up period (Bittner et al. EBioMedicine 2020;56:102807; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC7251380/pdf/main.pdf). Baseline NfL levels were 12.5 pg/mL in RRMS and 10.1 pg/mL in CIS (9.1 pg/mL in CIS patients according to McDonald 2017 criteria). Baseline NfL levels were higher in patients with >9 T2 lesions, Gd+ lesions or recent relapses. NfL…