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Novel anti-CD20 monoclonal approved in Canada for MS

January 27, 2021

…for hepatitis B reactivation and progressive multifocal leukoencephalopathy (PML). Ofatumumab is a fully human anti-CD20 MAb, in contrast to rituximab (chimeric) and ocrelizumab (humanized). It binds specifically to a distinct CD20 epitope and induces cell lysis primarily through complement-dependent cytotoxicity (CDC). The half-life is about 15 days in men and 17 days in women. Following administration of ofatumumab, B cells are depleted to belo…

COVID vaccine guidance for MS patients

January 22, 2021

…ineGuidance. Note that the U.S. guidance has not been adapted for Canada and links in the article may not apply. https://cnmsc.ca/RecommendationsCovid19Vaccines. Recommendations for policy-makers. Health Canada: www.canada.ca/en/public-health/services/immunization/national-advisory-committee-on-immunization-naci/guidance-prioritization-initial-doses-covid-19-vaccines.html. COVID vaccine tracker: https://globalnews.ca/news/7583050/covid-19-vaccine-…

Multiple sclerosis 2021 – a look ahead

January 13, 2021

…ons (www.canada.ca/en/public-health/services/immunization/national-advisory-committee-on-immunization-naci/recommendations-use-covid-19-vaccines.html). These are recommendations rather than contraindications: NACI also states that vaccine may be offered if the benefits outweigh the potential risks. There will be similar safety and effectiveness considerations with the next-generation COVID vaccines when they become available. There are also concer…

This just in – Winners of the 2020 Awards in Multiple Sclerosis

December 16, 2020

…ponse? (Bar-Or et al. Neurology 2020;95:e1999-e2008). The answer: Yes. Need-to-Know Award: Winner: The Global Data Sharing Initiative, which quickly assembled data on MS patients who contracted COVID and the effects of DMTs on clinical outcomes. The much-anticipated findings were presented at ACTRIMS/ECTRIMS 2020 and published in September (Peeters et al. Mult Scler 2020;26:1157-1162). Sunny Days Research Prize: Winner: The Sunshine Health Foundat…