AAN 2023 HIGHLIGHTS – MONDAY, APRIL 24
April 24, 2023…reached EDSS ≥4.0. The prediction of progressive MS was improved with the combination of serum neurofilament-light chain (sNfL) and glial fibrillary acid protein in CSF (cGFAP) compared to either measure alone. NfL generally reflects neuroaxonal damage due to disease activity; GFAP is a marker of astrocyte activation and neurodegeneration. Patients in the highest quintiles of both measures had a 5.5-fold higher risk of reaching EDSS ≥4.0 and a 3….