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REPORT FROM EAN 2024 – WEDNESDAY, JULY 3, 2024

…ars) with mild cognitive impairment or Alzheimer dementia (Jiang et al. EAN 2024;OPR-108). Baseline ChP volume was larger in AD patients compared with MCI patients or healthy controls. ChP volume enlargement was correlated with lower Aβ42 and Aβ40 levels, as well as lower MMSE and MoCA scores. ChP volume was a better indicator of the presence or absence of cerebral Aβ42 deposition than hippocampal volume. Baseline ChP volume was also predictive of…

REPORT FROM EAN 2024 – TUESDAY, JULY 2, 2024

…GHLIGHTS – TUESDAY EDITION NfL higher in MOGAD vs. MS The MULTIMOGAD study compared serum samples obtained within three months of disease onset from patients with MOG antibody disease (MOGAD) and MS (Villacieros-Alvarez et al. EAN 2024;OPR-065). Baseline NfL levels were higher in MOGAD; higher sNfL values were associated with a higher risk of a second relapse in MOGAD patients with optic neuritis. In contrast, OCBs were more common at onset in MS…

Inertia and uncertainty: is MS treatment truly optimized?

…This is consistent with the criteria outlined in treatment optimization recommendations (Freedman et al. Can J Neurol Sci 2020;47:437-455), but fails to explain the suboptimal use of higher-efficacy DMTs even when clinically indicated. Several other factors may play a role in the underusage of highly effective therapies. Neurologists who do not specialize in MS are less likely to escalate treatment even in cases of severe MS (Saposnik et al. Mult…

Geographic determinants of health: location, location

…s-covid-19/enhancing-access-principle-based-recommendations-equity/based-recommendations-equity-en.pdf). For example, a NARCOMS survey found that telehealth video visits were less common among disadvantaged groups, such as the elderly and those with greater impairments (Marrie et al. Neurol Clin Pract 2022;12:223-233). Telephone contact can be made in rural areas where videoconferencing is unavailable but generally provides suboptimal care (Giacom