Recent imaging studies in multiple sclerosis have focused on the association between cognitive dysfunction and grey-matter tissue loss, most notably of the cerebral cortex and thalamus. For example, at the American Academy of Neurology annual meeting, an analysis of the SPRINT-MS trial proposed that lower thalamic volume at baseline may be a useful predictor of physical, cognitive and visual disability in progressive MS (Nicholson et al. AAN 2022;S12.007). Thalamic volume at the time of relapse may also be predictive of cognitive recovery as assessed by the Symbol Digit Modalities Test (SDMT) (Weinstock et al. AAN 2022;P14.010). As such, thalamic volume (but not T2 lesion volume in this study) may serve as a marker of cognitive reserve. Read More
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6 criteria to improve PMS outcomes
May 2, 2022Click here to take the survey on Improving PMS outcomes.
Canadian researchers have proposed six criteria that must be met for a disease-modifying therapy (DMT) to be effective in progressive multiple sclerosis (Yong & Yong. Nat Rev Neurol 2022;18:40-55). Over a dozen DMTs are currently available but they generally have limited effectiveness in slowing the neurodegeneration that underlies disability progression.
AAN report: long-term data for anti-CD20s, BTK inhibitors
April 25, 2022A number of new studies have provided data on the long-term safety and efficacy of high-efficacy disease-modifying therapies in MS. The data were presented at the American Academy of Neurology (AAN) annual meeting, held April 2-7 in Seattle, Washington. The following is a summary of key studies. Read More
CLINICAL CASES IN MS – CASE 4: WORSENING SYMPTOMS IN A WOMAN WITH STABLE EDSS
April 21, 2022Click here to watch Dr. Daniel Selchen discuss the case and the responses to the survey.
Kay, 39 years old, is sales clerk at a downtown department store. In 2009, at age 27 years, she was diagnosed with RRMS. Her initial presentation was optic neuritis, but she subsequently developed brainstem symptoms, including mild vertigo and difficulty swallowing. There was no family history of demyelinating or autoimmune disorders. There was no significant medical history and no comorbidities. Read More