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Cladribine tablets – Updated efficacy and safety results

…cy, Summary of product characteristics, August 22, 2017. Free full text at www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004230/WC500234561.pdf No head-to-head trials have compared cladribine tablets with other disease-modifying therapies. To date, only one preliminary study from the MSBase group has examined this issue using a propensity score-matched analysis (Kalincik et al. ECTRIMS 2017; abstract P1138). The da…

Emerging Treatment Goals in Schizophrenia – Toward Functional Recovery

…er et al. Schizophr Res 2017; epublished April 19, 2017, free full text at www.schres-journal.com/article/S0920-9964(17)30199-8/pdf). At the end of one year (core + extension), the mean change from baseline in QLS score was 11 points, which is more than double the minimally clinically important difference. Taken together, these results suggest that sustainable functional recovery is achievable with effective LAI antipsychotic therapy. While social…

ECTRIMS 2017 DAILY REPORT – THURSDAY EDITION

…s diagnosed at a younger age (4.3/1000 PY if age 20-40 years at diagnosis) compared to an older age (11.5/1000 PY if older than 40 years). These results support previous reports of higher mortality rates in patients with MS. Back to top NfL examined as potential biomarker Numerous biomarkers have been proposed for predicting conversion from CIS: OCBs, kappa free-light chain, IgG against neurotropic viruses, chitinase-3-like protein-1, soluble CD27…

Cladribine: intermittent immunosuppression in MS

…thylation (Schreiner & Miravalle. J CNS Dis 2012;4:1-14; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3619698/pdf/jcnsd-4-2012-001.pdf). This may be relevant to efficacy, as noted above, and to safety. Hypermethylation of tumour suppressor genes is known to promote some malignancies through gene silencing. The hypomethylating effects of cladribine have been demonstrated in leukemic cell lines (Wyczechowska et al. Biochem Pharmacol 2003;6…

New findings on gut microbiome and MS

…s studies have identified alterations in microbiome species in MS patients compared to healthy controls (Jangi et al. Nat Commun 2016;7:12015; Miyake et al. PLoS One 2015;10:e0137429). These alterations were associated with variations in the expression of genes involving interferon and NF-kappaB signalling in T cells and monocytes. Also noteworthy is that vitamin D, as well as some disease-modifying therapies used in MS (e.g. glatiramer acetate, d…