…(27.7%) and antidepressants (26.6%). Use of contraceptives was higher in the non-polypharmacy group (15.0% vs. 8.7%). Polypharmacy was more common in patients with comorbidities, both in the inpatient group (87.4% vs. 61.0% with no comorbidity) and in the outpatient group (46.2% vs. 11.8% with no comorbidity). Specific comorbidities in this study were not provided. A meta-analysis reported the most prevalent comorbid conditions in MS patients were…

…mas et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e228; free full text at www.ncbi.nlm.nih.gov/pmc/articles/pmid/27213173/). A cytokine storm was reported in the one patient who died of hemorrhagic stroke. Cytokine syndrome may manifest clinically as pyrexia, headache, malaise and urticarial rash, and may be associated with a transient worsening of neurological symptoms (Moreau et al. Brain 1996;119:225-237). The incidence of cytokine release syn…