…Report from the 163rd annual meeting of the American Psychiatric Association, New Orleans LA, May 22-26, 2010 – Two recent reports suggest that maintenance antidepressants have limited efficacy in preventing relapses in patients with major depressive disorder. Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…
Memantine is an NMDA (N-methyl D-aspartate) receptor antagonist currently used in the treatment of Alzheimer’s disease. NMDA receptors appear to mediate oligodendrocyte injury and damage to the myelin sheath, and Canadian researchers have speculated that blocking these receptors may be clinically useful in MS (Stys & Lipson. Trends Pharmacol Sci 2007; 28: 561-566). Subscribe to read more It takes 30 seconds or login using your email address Pleas…
…A long-term follow-up analysis of patients enrolled in the pivotal trial of beta-interferon-1b reports that patients with relapsing-remitting MS in the active treatment arm have improved long-term mortality compared to patients in the placebo arm (Reder et al. Neurology 2010; 74: 1877-1885). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…
…A systematic review of mirtazapine treatment trials has found that there is inadequate reporting of adverse events in therapeutic trials of major depression (Watanabe et al. CNS Drugs 2010; 24: 35-53). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…
…patients with Parkinson’s disease (Zesiewicz et al. Neurology 2010; 74: 924-931; free full text at www.neurology.org/cgi/reprint/74/11/924). Nonmotor symptoms addressed included sleep disorders (restless legs syndrome, periodic limb movements of sleep, excessive daytime somnolence, insomnia, REM sleep behaviour disorder), autonomic dysfunction (GI disorders, orthostatic hypotension, sexual dysfunction, urinary incontinence), fatigue and anxiety. S…