Negative trial of DHA supplementation in Alzheimer’s disease


Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid that has been shown in vitro and in animal models to alter beta-amyloid accumulation and to have anti-apoptotic activity (Oksman et al. Neurobiol Dis 2006; 23: 563-572). For a recent review see Jicha & Markesbery. Clin Interv Aging 2010; 5: 45-61; free full text at

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