Characterizing demyelinating lesion formation and neurodegeneration


REPORT FROM THE EUROPEAN CHARCOT FOUNDATION ANNUAL MEETING – BAVENO, ITALY, NOVEMBER 28-30, 2013 – A decade ago, four immunopathological patterns of demyelination were described for MS lesions (Lucchinetti et al. Ann Neurol 2000;47:707-717). Patterns I and II resembled a T-cell-mediated and T-cell plus antibody-mediated autoimmune encephalomyelitis, while patterns III and IV were suggestive of a virus- or toxin-mediated demyelination rather than autoimmune processes. This lesion heterogeneity is evident early in MS; patterns converge to one of T cell, macrophage and microglia involvement later in the disease course (Lassmann H. ECF 2013).

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