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CLINICAL CASES IN MS – A case of worsening mobility during the pandemic


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Michelle, 46, is a bank manager who was diagnosed with MS in 1996. She was initially treated with interferon-beta-1a 44 ug. She experienced ongoing clinical and radiological activity and was switched to natalizumab in 2013. She remained stable for seven years. In February 2020, Michelle noted that she used to be able to walk 2 km but could now only manage about 1 km. Her EDSS score showed no change over the past year. EDSS score was 3.0 (motor 2, cerebellar 2, sensory 2). She was started on 4-aminopyridine but obtained no benefit. Read More

AAN update on anti-CD20 agents: long-term data



Long-term treatment of multiple sclerosis with anti-CD20 therapies is associated with sustained efficacy and a favourable safety profile, according to new data presented at the American Academy of Neurology (AAN) annual meeting, held April 22-27 in Boston. The following summarizes some of the key data that were presented. Read More

Emerging role of CHI3L1 as MS biomarker


Chitinase-3-like 1 (CHI3L1) is a glycoprotein produced by monocytes, microglia and activated astrocytes that has been proposed as a diagnostic and prognostic biomarker of progression in MS. A recent meta-analysis of 20 studies reported that CHI3L1 levels in CSF were strongly correlated with the clinical course (Floro et al. Neurol Neuroimmunol Neuroinflamm 2022;9:e1164). Levels were higher in converting clinically isolated syndrome (CIS) vs. non-converting CIS; in MS vs. CIS or healthy controls; and in PPMS vs. RRMS. Read More



Selected highlights from the American Academy of Neurology annual meeting, Boston, MA, 22-27 April 2023.

April 25 Edition
April 24 Edition

COVID-19 infections with ocrelizumab
Postpartum relapse and DMTs
NMOSD frequently misdiagnosed
sNfL after menopause
Pregnancy risks with fingolimod
Phase II study of stem-cell therapy in PMS
Low rate of ocrelizumab failure
DMT non-starters common in California
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