‘Burned-out MS’ (BOMS) is a term that has arisen recently in the multiple sclerosis literature. An early definition of BOMS described patients with a high EDSS score after a prolonged course of illness who had atrophy but no inflammatory activity on MRI (Bhatia & Singh. Ann Indian Acad Neurol 2019;22:131-136). The MS Association of America described BOMS as a form of inactive MS in which disease progression slows dramatically later in life. This is not a new phenotype since these definitions overlap with that of stable disease (not active/without progression) in the 2013 revisions (Lublin et al. Neurology 2014;83:278-286). The key difference and controversy is that BOMS presumes that no further MS-related progression will occur. Read More