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PRL detected in optic chiasm

 

A newly-published postmortem study has reported that paramagnetic rim lesions (PRL) can occur in the optic chiasm in MS patients (Lockhart et al. Neurology 2026;106:e214515). This is the first report of PRLs detected in the anterior visual pathway. PRLs are most commonly seen in periventricular and deep white-matter lesions in MS patients using 3T or 7T MRI. Read More

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BTK inhibitors – a look ahead

 

Important new data are expected this year on the efficacy and safety of Bruton’s tyrosine kinase (BTK) inhibitors, a new class of disease-modifying therapies in development for multiple sclerosis. Read More

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PIRA – can it be applied to NMOSD?

 

Progression independent of relapse activity (PIRA) was a term coined a decade ago to describe the insidious disability worsening that occurs in multiple sclerosis during relapse-free periods due to neurodegenerative processes such as smouldering inflammation. A new study reports that 2.5% of patients with neuromyelitis optica spectrum disorder (NMOSD) also have PIRA events during long-term follow-up (Kang et al. Neurol Neuroimmunol Neuroinflamm 2026;13:e200533). Read More