An analysis has been conducted to determine the minimum clinically important difference in the positive and negative syndrome scale (PANSS) during antipsychotic treatment based on data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study (Hermes et al. J Clin Psychiatry 2012;73:526-532). Data were available for 1,442 patients to link PANSS scores and clinician/patient ratings on the Clinical Global Impressions (CGI) scale.