The University of Buffalo MS group has reported that comorbid cardiovascular disease appears to contribute to more rapid brain tissue loss in patients with multiple sclerosis (Jakimovski et al. Eur J Neurol 2018; epublished August 13, 2018).
The study compared 194 MS patients and 43 healthy controls over a 5-year period. Brain atrophy was evaluated with 3T MRI. MS patients with cardiovascular disease had a higher loss of white matter volume (-4.2% vs. -0.7%) and whole-brain volume (-3.4% vs. -1.6%) compared to MS patients without heart disease.