Hockey and head injury – report


The Ice Hockey Summit III has published a list of action items to address the diagnosis, clinical care and prevention of sports-related concussion (Smith et al. Curr Sports Med Rep 2019;18:23-34). The report follows on guidelines on mild traumatic brain injury in children by the U.S. Centers for Disease Control (Lumba-Brown et al. JAMA Pediatr 2018;172:e182853), and guidelines on the management of concussion by the American Academy of Neurology (Giza et al. Neurology 2013;80:2250-7). Read More

Two trials terminated in Alzheimer’s disease


Roche has announced that it has terminated two phase III trials of crenezumab, a monoclonal antibody targeting beta-amyloid. The trials, CREAD 1 and CREAD 2, were evaluating the agent in prodromal to mild Alzheimer’s disease. Read More


Rare cases of stroke reported with alemtuzumab


The U.S. Food and Drug Administration (FDA) has issued a black-box warning about a risk of stroke and arterial dissection in patients with multiple sclerosis who have been exposed to alemtuzumab (…).  The announcement was issued on November 29, 2018 and a black-box warning was added to the U.S. product label. The Canadian product monograph had not been updated at the time of writing. Read More