Neurology

Hockey and head injury – report

 

The Ice Hockey Summit III has published a list of action items to address the diagnosis, clinical care and prevention of sports-related concussion (Smith et al. Curr Sports Med Rep 2019;18:23-34). The report follows on guidelines on mild traumatic brain injury in children by the U.S. Centers for Disease Control (Lumba-Brown et al. JAMA Pediatr 2018;172:e182853), and guidelines on the management of concussion by the American Academy of Neurology (Giza et al. Neurology 2013;80:2250-7). Read More

Two trials terminated in Alzheimer’s disease

 

Roche has announced that it has terminated two phase III trials of crenezumab, a monoclonal antibody targeting beta-amyloid. The trials, CREAD 1 and CREAD 2, were evaluating the agent in prodromal to mild Alzheimer’s disease. Read More

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Rare cases of stroke reported with alemtuzumab

 

The U.S. Food and Drug Administration (FDA) has issued a black-box warning about a risk of stroke and arterial dissection in patients with multiple sclerosis who have been exposed to alemtuzumab (www.fda.gov/Drugs/DrugSafety/ucm624247.htm?fbclid=IwAR2eBbqp24E0J3VIk8jbUZZ5pet…).  The announcement was issued on November 29, 2018 and a black-box warning was added to the U.S. product label. The Canadian product monograph had not been updated at the time of writing. Read More

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